Module 2 - Vector Persistence and Integration Site Analyses
We apply new approaches to identify viral vector integration sites (IS) based on Next Generation Sequencing (NGS). Referring to our unique experience with cancer genomics studies we offer partial or complete vector genome Target Enrichment Sequencing (TES). Results yield information on clonality, quantitative individual clonal contributions and vector genome stability. Enrichment of cellular subgenomic DNA in parallel to vector sequences further allows definition of vector copy number in sample.